Aaron Klug

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Aaron Klug

Aaron Klug 1979.jpg
Aaron Klug in 1979
Born (1926-08-11)11 August 1926[1]
Želva, Lithuania
Died 20 November 2018(2018-11-20) (aged 92)
Nationality British
Education Durban High School
Alma mater
Known for Crystallographic electron microscopy[2]
Spouse(s)
Liebe Bobrow (m. 1948)
[1]
Children Two[1]
Awards
Scientific career
Fields
Institutions
Thesis The kinetics of phase changes in solids (1953)
Doctoral advisor Douglas Hartree[6]
Website www2.mrc-lmb.cam.ac.uk/about-lmb/archive-and-alumni/alumni/aaron-klug/

Sir Aaron Klug OM FRS FMedSci HonFRMS[3] (11 August 1926 – 20 November 2018)[7][8] was a Lithuanian-born, South African-educated, British biophysicist, and winner of the 1982 Nobel Prize in Chemistry for his development of crystallographic electron microscopy and his structural elucidation of biologically important nucleic acid-protein complexes.[9][10][11][12][13][1][14]

Early life and education

From right to left: Prince Claus of the Netherlands, Aaron Klug and his wife Liebe Bobrow, 1979

Klug was born in Želva, Lithuania to Jewish parents Lazar, a cattleman, and Bella (née Silin) Klug, with whom he moved to South Africa at the age of two.[15][16] He was educated at Durban High School.[1] Paul de Kruif's book Microbe Hunters aroused his inteerst in microbiology.[17]

He started to study microbiology, but then moved into physics and maths, graduating with a Bachelor of Science degree at the University of the Witwatersrand Johannesburg. He studied physics and obtained his Master of Science degree at the University of Cape Town[1] He was awarded an 1851 Research Fellowship from the Royal Commission for the Exhibition of 1851,[18] which enabled him to move to England, completing his PhD in research physics at Trinity College, Cambridge in 1953.[19]

Career and research

Following his PhD, Klug moved to Birkbeck College in the University of London in late 1953, and started working with virologist Rosalind Franklin in the lab of crystallographer John Bernal. This experience aroused a lifelong interest in the study of viruses, and during his time there he made discoveries in the structure[20] of the tobacco mosaic virus. In 1962 he moved to the newly built Medical Research Council (MRC) Laboratory of Molecular Biology (LMB) in Cambridge. Over the following decade Klug used methods from X-ray diffraction, microscopy and structural modelling to develop crystallographic electron microscopy in which a sequence of two-dimensional images of crystals taken from different angles are combined to produce three-dimensional images of the target. He studied the structure of transfer RNA, and found what is known as zinc fingers as well as the neurofibrils in Alzheimer's disease.[17]

Also in 1962 Klug had been offered a teaching Fellowship at Peterhouse, Cambridge. After receiving the Nobel Prize in Chemistry in 1982, he went on teaching because he found the courses interesting and was later made an Honorary Fellow at the College.[1][21]

Between 1986 and 1996 he was director of the Laboratory of Molecular Biology in Cambridge. Klug served[when?] on the Advisory Council for the Campaign for Science and Engineering.[22] He also served[when?] on the Board of Scientific Governors at The Scripps Research Institute.[23] He and Dai Rees approached the Wellcome Trust to found the Wellcome Sanger Institute, which was a key player in the Human Genome Project.[17]

Awards and honours

Klug was awarded the Louisa Gross Horwitz Prize from Columbia University in 1981. He was knighted by Elizabeth II in 1988.[24] He was elected a Fellow of the Royal Society (FRS) in 1969[3] and served as President from 1995–2000. He was appointed Order of Merit in 1995 – as is customary for Presidents of the Royal Society. His certificate of election to the Royal Society reads:

In 2005 he was awarded South Africa's Order of Mapungubwe (gold) for exceptional achievements in medical science.[26] He was elected a Fellow of the Academy of Medical Sciences (FMedSci).[when?][27]

Personal life

Klug married Liebe Bobrow in 1948.[1] Though Klug had faced discrimination in South Africa, he remained religious and according to Sydney Brenner, he became more religious in his older age.[28]

References

  1. ^ a b c d e f g h i Anon (2015). Klug, Sir Aaron. ukwhoswho.com. Who's Who (online Oxford University Press ed.). A & C Black, an imprint of Bloomsbury Publishing plc. doi:10.1093/ww/9780199540884.013.U23297. closed access publication – behind paywall (subscription required)
  2. ^ Shafrir, E. (1994). "Aaron Klug--a pioneer of crystallographic electron microscopy". Israel journal of medical sciences. 30 (9): 734. PMID 8088991.
  3. ^ a b c "Sir Aaron Klug OM FRS". London: Royal Society. Archived from the original on 2015-11-07.
  4. ^ "Honourary Fellows". www.rms.org.uk. Retrieved 20 February 2017.
  5. ^ "Honorary Fellows Past and Present". www.rms.org.uk. Retrieved 20 February 2017.
  6. ^ Aaron Klug at the Mathematics Genealogy Project
  7. ^ Obituaries, Telegraph (22 November 2018). "Sir Aaron Klug, OM, scientist who won a Nobel Prize for his work on electron microscopy and chromosomes – obituary" – via www.telegraph.co.uk.
  8. ^ "Aaron Klug (1926 - 2018) - MRC Laboratory of Molecular Biology". 21 November 2018.
  9. ^ Nobel Foundation (18 October 1982). "The Nobel Prize in Chemistry 1982" (Press release). The Royal Swedish Academy of Sciences. Retrieved 13 September 2007.
  10. ^ Wakabayashi, K. (1983). "Accomplishment of Dr. Aaron Klug, winner of Nobel prize in chemistry, 1982". Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme. 28 (2): 156–157. PMID 6342048.
  11. ^ Shampo, M. A.; Kyle, R. A. (1994). "Sir Aaron Klug--Nobel Prize winner for chemistry". Mayo Clinic Proceedings. 69 (6): 556. doi:10.1016/S0025-6196(12)62247-2. PMID 8189761.
  12. ^ "Aaron Klug biography". nobelprize.org.
  13. ^ Finch, John (2008). A Nobel Fellow On Every Floor. Medical Research Council. ISBN 978-1-84046-940-0. this book is all about the MRC Laboratory of Molecular Biology, Cambridge.
  14. ^ Aaron Klug archive collection - Churchill Archives Centre finding aid.
  15. ^ "The Papers of Sir Aaron Klug". Churchill Archives Centre. Retrieved 2016-03-03.
  16. ^ "Desert Island Discs – Castaway : Sir Aaron Klug first broadcast 2002-05-12". BBC.
  17. ^ a b c Geoff Watts. Aaron Klug. Obituary The Lancet. Volume 392, ISSUE 10164, P2546, December 15, 2018. DOI:10.1016/S0140-6736(18)33109-X
  18. ^ 1851 Royal Commission Archives
  19. ^ Klug, Aaron (1953). The kinetics of phase changes in solids. proquest.com (PhD thesis). University of Cambridge.
  20. ^ Amos, L.; Finch, J. T. (2004). "Aaron Klug and the revolution in biomolecular structure determination". Trends in Cell Biology. 14 (3): 148–152. doi:10.1016/j.tcb.2004.01.002. PMID 15003624.
  21. ^ "Eminent Petreans". University of Cambridge. Archived from the original on 2015-06-26.
  22. ^ "Advisory Council of the Campaign for Science and Engineering". Sciencecampaign.org.uk. Archived from the original on 28 August 2010. Retrieved 11 February 2011.
  23. ^ "Scripps Research Scientific Board Meets in Florida". Scripps Research Institute. 2004-01-26. Retrieved 2016-03-03.
  24. ^ "Aaron Klug (1926–)". Jewish Virtual Library. Retrieved 7 November 2009.
  25. ^ "Certificate of Election EC/1969/19: Aaron Klug". London: Royal Society. Archived from the original on 8 November 2015.
  26. ^ "National Orders awards 27 September 2005". State of South Africa. 29 September 2005. Archived from the original on 30 September 2007. Retrieved 13 September 2007.
  27. ^ "Sir Aaron Klug - The Academy of Medical Sciences". acmedsci.ac.uk.
  28. ^ Hargittai, Istva'n & Magdolna. 2006. Candid Science VI: More Conversations with Famous Scientists. Imperial College Press, p. 33

Further reading

  • Aaron Klug tells his life story at Web of Stories
  • Aaron Klug interviews with Harry Kroto
  • Aaron Klug article by Bob Weintraub
  • Aaron Klug interviewed by Alan Macfarlane 11 December 2007 (film)
  • Listen to an oral history interview with Aaron Klug – a life story interview recorded for National Life Stories at the British Library
  • Aaron Klug, Nobel Luminaries Project, The Museum of the Jewish People at Beit Hatfutsot
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